✦ LIBER ✦
Long-term survival of a patient with leptomeningeal involvement by nasopharyngeal carcinoma after treatment with high-dose intravenous methotrexate
✍ Scribed by Carole Fakhry; Gopal Bajaj; Nafi Aygun; William Westra; Maura Gillison
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 672 KB
- Volume
- 34
- Category
- Article
- ISSN
- 1043-3074
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✦ Synopsis
Abstract
Background.
Nasopharyngeal carcinoma with leptomeningeal involvement is rare and typically has poor prognosis.
Methods and Results.
We present a case report of a patient with nasopharyngeal carcinoma who was treated with high‐dose intravenous methotrexate and remains asymptomatic and without clinical evidence of disease 6 years later.
Conclusions.
Systemic high‐dose methotrexate should be evaluated in the treatment of advanced nasopharyngeal carcinoma with central nervous involvement. © 2010 Wiley Periodicals, Inc. Head Neck, 2012