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Long-term survival in chronic myelocytic leukemia after a first primary malignancy

✍ Scribed by Hermann Brenner; Adam Gondos; Dianne Pulte


Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
359 KB
Volume
33
Category
Article
ISSN
0145-2126

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When marrow cells from Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML) patients are placed into long-term culture, Ph-positive progenitor numbers typically decline rapidly. Karyotypically normal cells derived from persisting, but previously undetectable, precursors can then