Long-term survival data and prognostic factors of a complete response to chemotherapy in patients with head and neck cancer treated with platinum-based induction chemotherapy: A hellenic co-operative oncology group study
✍ Scribed by Fountzilas, George ;Kosmidis, Paris ;Avramidis, Vasilios ;Nikolaou, Angelos ;Kalogera-Fountzila, Anna ;Makrantonakis, Paris ;Bacoyiannis, Charalambos ;Samantas, Epaminontas ;Skarlos, Dimosthenis ;Daniilidis, John
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 156 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0098-1532
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✦ Synopsis
A group of 154 patients with locally advanced head and neck cancer, treated with platinum-based induction chemotherapy, were followed up for 5 years and several pretreatment characteristics were analyzed for possible correlation to a complete response (CR) to chemotherapy, time to progression (TTP) and overall survival (OS). Clinical stage (p = 0.0024) and a history of smoking (p = 0.0125) were selected as important prognostic factors for CR by step wise logistic regression. We also identified response to chemotherapy (p = 0.0120), age (p = 0.0066), clinical stage (p = 0.0363), N stage (p = 0.0028), and tumor grade (p = 0.0101) as significant prognostic variables for TTP. Response to chemotherapy (p < 0.0001) and age (p = 0.0017) were found also significant for OS. These long-term prognostic factors which retain their prognostic significance after several years of follow-up could be helpful in the design of future trials in this patient population.