𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Long-term studies of pancreas allotransplantation in experimental diabetes mellitus

✍ Scribed by Dr. Sun Lee; Michael H. Scott; Diane Yancey; Jennifer Allen; Eil Sung Chang; Francis Chisari; A. R. Moossa

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
446 KB
Volume
9
Category
Article
ISSN
0738-1085

No coin nor oath required. For personal study only.

✦ Synopsis

Pancreaticoduodenal (PD) allografts (Brown Norway-alloxan-diabetic rats, n = 190) were treated with cyclosporin A (Cy-A) 10 mg/kg/daily and compared with nondiabetics with Cy-A treatment (n = 55), diabetics (n = 50), and diabetics with Cy-A treatment (n = 45). Body weight, blood sugar, blood insulin, blood urea nitrogen (BUN), and creatinine were monitored periodically; there were marked elevations of BUN and creatinine levels, indicating probably nephrotoxicity of Cy-A at this dosage. Some islet cell atrophy in the PD allografts was noted at the conclusion of the study. With respect to the immunosuppressive effect of Cy-A in alloxan diabetic rats, Brown Norway PD transplants into Lewis rats were successful and free of rejection for as long as 15 months post-transplantation. The body weight of these PD transplanted rats, however, never approached values representative of the nondiabetic rats. In our experience, the PD allograft model is acceptable in the clinical situation, particularly in children if the microsurgical technique is mastered and if the Cy-A regimen is used in combination with other immunosuppressant(s).

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