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Long-term stability of a coronary stent coating post-implantation

✍ Scribed by Lewis, A. L. ;Furze, J. D. ;Small, S. ;Robertson, J. D. ;Higgins, B. J. ;Taylor, S. ;Ricci, D. R.

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
648 KB
Volume
63
Category
Article
ISSN
0021-9304

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✦ Synopsis

Abstract

A coronary stent possessing a phosphorylcholine‐based polymer coating was removed from a human patient 6 months after implantation and analyzed for the presence of the coating. An atomic force microscopy (AFM) technique has been employed to scrape away several 10‐μm^2^ areas on the struts of the explanted stent. Scanning‐electron microscopy (SEM) and tapping‐mode AFM confirmed a surface coating had been removed in each case. Cross‐sectional analysis and force‐of‐removal measurements showed that both coating depth and hardness were characteristic of that for the phosphorylcholine‐ (PC‐) based coating prior to implantation. AFM amplitude‐phase and distance curves from the explanted stent were comparable to those obtained when an unused stent was analyzed. Furthermore, laser ablation high‐resolution inductively coupled‐plasma mass spectometery (LA‐HR‐ICP‐MS) was used to detect the low level of silicon present in the PC coating after explantation. The results from these techniques confirm that the stent coating is the original PC polymer and is not of biological origin, and support the long‐term stability of the coating in vivo. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res (Appl Biomater) 63: 699–705, 2002

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