Long-term prophylaxis in severe haemophilia seems to preserve bone mineral density

Long-term serotonin administration leads

Long-term serotonin administration leads to higher bone mineral density, affects bone architecture, and leads to higher femoral bone stiffness in rats

✍ Björn I. Gustafsson; Irene Westbroek; Jan H. Waarsing; Helge Waldum; Erik Sollig 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 217 KB

## Abstract New evidence suggests a control of bone mass by the central nervous system. We have previously shown that functional serotonin receptors are present in bone cells and that serotonin stimulates proliferation of osteoblast precursor cells in vitro. In the present study we investigated the