Long-Term Potentiation Is Impaired in Middle-Aged Rats: Regional Specificity and Reversal by Adenosine Receptor Antagonists

Hippocampal plasticity induced by primed

Hippocampal plasticity induced by primed burst, but not long-term potentiation, stimulation is impaired in area CA1 of aged fischer 344 rats

✍ Christopher I. Moore; Michael D. Browning; Dr. Gregory M. Rose 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 870 KB

The effect of two types of electrical stimulation designed to induce long-lasting plasticity of the Schafferkommissural inputs to CA1 pyramidal neurons was investigated using in vitro hippocampal slices made from young (3-6 month) and old (24-27 month) Fischer 344 rats. The first stimulation paradig