The influence of the neural cell adhesion molecule L1 on hippocampal long-term potentiation (LTP) was investigated using transgenic mice ectopically expressing L1 in astrocytes (GFAP-Ll). L1 is a member of the immunoglobulin superfamily of homophilic adhesion molecules predominantly expressed in neu
β¦ LIBER β¦
Long-term potentiation in mice lacking the neural cell adhesion molecule L1
β Scribed by Tim Bliss; Mick Errington; Eric Fransen; Jean-Marie Godfraind; Julie A Kauer; R.Frank Kooy; Patricia F Maness; Andrew J.W Furley
- Book ID
- 114318014
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 62 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0960-9822
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Neural recognition molecules such as the neural cell adhesion molecule (NCAM) have been implicated in synaptic plasticity, including long-term potentiation (LTP), sensitization, and learning and memory. The major isoform of NCAM carrying the longest cytoplasmic domain of all NCAM isoforms (NCAM180)