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Long-term niacin treatment induces insulin resistance and adrenergic responsiveness in adipocytes by adaptive downregulation of phosphodiesterase 3B

✍ Scribed by Heemskerk, M. M.; van den Berg, S. A. A.; Pronk, A. C. M.; van Klinken, J.-B.; Boon, M. R.; Havekes, L. M.; Rensen, P. C. N.; van Dijk, K. W.; van Harmelen, V.

Book ID: 127108528
Publisher: The American Physiological Society
Year: 2014
Tongue: English
Weight: 176 KB
Volume: 306
Category: Article
ISSN: 0193-1849
DOI: 10.1152/ajpendo.00641.2013

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Long-term niacin treatment induces insul

Long-term niacin treatment induces insulin resistance and adrenergic responsiveness in adipocytes by adaptive downregulation of phosphodiesterase 3B

✍ Heemskerk, M. M.; van den Berg, S. A. A.; Pronk, A. C. M.; van Klinken, J.-B.; B 📂 Article 📅 2014 🏛 The American Physiological Society 🌐 English ⚖ 176 KB

The lipid-lowering effect of niacin has been attributed to the inhibition of cAMP production in adipocytes, thereby inhibiting intracellular lipolysis and release of nonesterified fatty acids (NEFA) to the circulation. However, long-term niacin treatment leads to a normalization of plasma NEFA level