Long-term histological changes in 1 millimeter polytetrafluoroethylene (gore-tex) prosthetic arterial grafts
✍ Scribed by Roslyn M. Samuels; John K. McGeachie; Francis J. Prendergast; Elizabeth A. Storrie
- Book ID
- 102947895
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 948 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0738-1085
No coin nor oath required. For personal study only.
✦ Synopsis
Vein grafts are used extensively to repair blood vessels. However, when suitable vein segments are unavailable, alternative graft materials must be used. This study tested the suitability of 1 mm diameter polytetrafluoroethylene (PTFE) grafts for smallcalibre arterial replacements. Grafts of 4mm length were insetted microsurgically into the iliac arteries of 26 rats. The grafts were removed between 3 and 22 months postoperatively and examined with light microscopy and scanning and transmission electron microscopy (SEM: TEM). Anastomotic intimal hyperplasia was minimal, consisting of a few smooth muscle cells extending 100-200 p, m onto the graft. The rest of the PTFE was covered with endothelium. In a few isolated areas, there was a subendothelial layer of smooth muscle, 2-1 0 cells thick. The short segments used in this study were highly successful, with an overall long-term patency rate of 80%. These grafts showed no evidence of excessive neo-intimal hyperplasia.