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Long-term haloperidol-treatment of mice: A change in β-adrenergic receptor responsiveness

✍ Scribed by R. Dunstan; D. M. Jackson

Publisher
Springer
Year
1979
Tongue
English
Weight
476 KB
Volume
44
Category
Article
ISSN
1435-1463

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The demonstration of a change in adrenergic receptor sensitivity in the central nervous system of mice after withdrawal from long-term treatment with haloperidol
✍ Robin Dunstan; David M. Jackson 📂 Article 📅 1976 🏛 Springer 🌐 English ⚖ 935 KB

Mice, administered haloperidol (3 mg/kg/d) in their drinking water for 21 days, displayed, 4 days after cessation of the haloperidol-treatment, marked locomotor stimulation to clonidine (100 or 500 mug/kg) which lasted for about 6 h. 25 mug clonidine/kg was inactive. Premedication with FLA-63 (25 mg