## ABSTRACT Several attempts to decrease sugar demand by introducing stevioside as a sugar substitute in children's food products have been made, but safety issues were concerned. This exploratory study investigated the effects of stevioside low dose (SL), high dose (SH) and low dose with inulin (S
‘Long-term feeding effects of stevioside sweetener on some toxicological parameters of growing rats’
✍ Scribed by Michael Carakostas
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 66 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0260-437X
- DOI
- 10.1002/jat.1756
No coin nor oath required. For personal study only.
✦ Synopsis
Long-term feeding effects of stevioside sweetener on some toxicological parameters of growing rats'
The recent publication by Awney et al. (2010) suggesting that oral exposure of growing rats to stevioside produces adverse effects on bone contains a number of technical inaccuracies, as well as inaccurate citations of the literature. These problems fall into two large areas: (1) analytical and sample handing errors; and (2) over-interpretation of results from a nonspecific assay that do not support the authors' conclusions.
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Five phenolic compounds, namely caffeic acid, sesamol, hydroquinone, catechol, and 4-methoxyphenol, were fed to groups of 30 male F344 rats at dietary levels of 2, 2, 0.8, 0.8, and 2%, respectively, for 2 years. Retardation of body weight and elevated relative liver weights were noted for all groups