This study was performed to evaluate the long-term functional nerve recovery after reconstruction of a 10-mm gap in the sciatic nerve of the rat, with a thin-walled nerve guide, composed of a biodegradable copolymer of DL-lactide and -caprolactone [p(DLLA--CL)]. To evaluate both motor and sensory ne
Long-term evaluation of degradation and foreign-body reaction of subcutaneously implanted poly(DL-lactide-?-caprolactone)
โ Scribed by den Dunnen, W. F. A. ;Robinson, P. H. ;van Wessel, R. ;Pennings, A. J. ;van Leeuwen, M. B. M. ;Schakenraad, J. M.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 424 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0021-9304
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โฆ Synopsis
The aim of this study was to evaluate the degra-within 12 months and that no lactide or โ-caprolactone crystals dation and foreign-body reaction of poly(DL-lactide-โ-capro-were formed. Furthermore, we conclude that the foreign-body lactone) PLA 85 CL 50 ) bars. This specific biomaterial is used for reaction of PLA 85 CL 50 is very mild. These properties make the the construction of nerve guides, which can be used in the amorphous copolymer of DL-lactide and โ-caprolactone reconstruction of short nerve gaps. Subcutaneously im-(50:50) suitable for the construction of nerve guides.
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