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Long-term effects of treatment on endocrine function in children with brain tumors

✍ Scribed by Dr Patricia K. Duffner; Michael E. Cohen; Stephen W. Anderson; Mary L. Voorhess; Margaret H. MacGillivray; Alvin Panahon; Martin L. Brecher

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
685 KB
Volume
14
Category
Article
ISSN
0364-5134

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✦ Synopsis

Fourteen children with brain tumors received endocrine evaluations at least one year following completion of cranial irradiation. Treatment consisted of operation (13 patients), craniospinal irradiation (6), whole brain irradiation (li), posterior fossa irradiation (3), and chemotherapy (10). Endocrine evaluation included bone age roentgenography and measurement of growth hormone (using sequential arginine and insulin stimulation), thyroxine, thyroid-stimulating hormone, plasma cortisol, testosterone, prolactin, and urinary follicle-stimulating hormone and luteinizing hormone.

Ten of I2 children (83%) had abnormal responses to both tests of growth hormone stimulation. All growth hormonedeficient patients treated prior to puberty and tested at least 2 years following completion of cranial irradiation had decelerated linear growth. Results of thyroid function tests were abnormal in 4 patients: 2 patients had evidence of primary hypothyroidism, and 2 showed secondary or tertiary hypothyroidism. Two patients had inadequate cortisol responses to insulin hypoglycemia. Urinary follicle-stimulating hormone and luteinizing hormone, serum prolactin, and serum testosterone levels were appropriate for age in all patients.

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