Long-term effects of postoperative total parenteral nutrition supplemented with glycylglutamine on subjective fatigue and muscle protein synthesis
✍ Scribed by Dr B. Petersson; A. von der Decken; E. Vinnars; J. Wernerman
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 401 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0007-1323
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✦ Synopsis
Abstract
Seventeen patients undergoing elective open chole-cystectomy were given conventional total parenteral nutrition either with (nine patients) or without (eight) glutamine supplementation of 20 g/day for 3 days after surgery and thereafter ordinary food for the following 27 days. Muscle protein synthesis, as assessed by the total concentration of ribosomes, decreased in control patients on day 3 following surgery and remained low on days 10, 20 and 30 (P < 0·05). In patients who received glutamine the total ribosome concentration was maintained on the third day after operation. Concurrently, the subjective feeling of fatigue increased on days 3 and 10 after surgery and the nitrogen balance was negative after operation in both groups, without any difference related to glutamine supplementation. Intravenous glutamine after surgery counteracts a decline in muscle protein synthesis only for as long as it is provided.