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Long-Term Effects of Amino-Bisphosphonates on Circulating γδ T Cells

✍ Scribed by Maurizio Rossini, Silvano Adami, Ombretta Viapiana…

Book ID
120757636
Publisher
Springer
Year
2012
Tongue
English
Weight
237 KB
Volume
91
Category
Article
ISSN
1432-0827

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## Abstract Nitrogen containing‐bisphosphonates (N‐BPs), widely used to treat bone diseases, have direct antitumor effects __via__ the inactivation of Ras proteins. In addition to the direct antitumor activities, N‐BPs expand gdγδT cells, which exhibit major histocompatibility complex‐unrestricted