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Long-term effect of FTY720 on lymphocyte count and islet allograft survival in mice

✍ Scribed by Longshan Liu; Changxi Wang; Xiaoshun He; Wenjun Shang; Ying Bi; Dong Wang

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
276 KB
Volume
27
Category
Article
ISSN
0738-1085

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✦ Synopsis

Abstract

This study was performed to observe the long‐term effect of FTY720 on lymphocyte count change and islet allograft survival. Diabetic C57BL/6 mice were given FTY720 (group 1, 0.5 mg/kg/day; group 2, 1.0 mg/kg/day) or its vehicle (group 3, controls) after transplantation. Median graft survival time was prolonged in a dose‐dependent manner (group 1, 84.5 days; group 2, >100 days, and group 3, 10 days, P < 0.01). Peripheral blood lymphocytes in groups 1 and 2 decreased to 23.81% and 12.59% compared with control group after FTY720 treatment. Lymphocytes from mesenteric lymph nodes and axillary nodes in groups 1 and 2 significantly increased on day 5, but decreased on day 14. Lymphocyte infiltration to the graft site was attenuated in groups 1 and 2. In conclusion, continuous FTY720 administration can induce and maintain lymphopenia, and inhibit lymphocytes from infiltrating the graft site so as to prolong islet allograft survival in mice. © 2007 Wiley‐Liss, Inc. Microsurgery 2007.

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