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Long-term depolarization regulates the α1ssubunit of skeletal muscle Ca2+channels and the amplitude of L-type Ca2+currents

✍ Scribed by Juan Escamilla; José M. Farías; Rubén García; María C. García; Jorge A. Sánchez

Publisher
Springer
Year
2001
Tongue
English
Weight
115 KB
Volume
442
Category
Article
ISSN
0031-6768

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✍ Eikichi Ihara; Katsuya Hirano; Mayumi Hirano; Junji Nishimura; Hajime Nawata; Hi 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 223 KB

The mechanism of down-regulation of L-type Ca(2+) channel (L-VOC) was investigated in rat aortic smooth muscle cells in primary culture. On culture days 3-5, the cells actively incorporated the 5-bromo-2'-deoxy-uridine (BrdU), and did not respond to K(+) depolarization nor express alpha(1C) subunit