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Long-term bone marrow cultures in Diamond-Blackfan anemia reveal a defect of both granulomacrophage and erythroid progenitors

✍ Scribed by Maria Alessandra Santucci; Gian Paolo Bagnara; Pierluigi Strippoli; Laura Bonsi; Lorenza Vitale; Roberto Tonelli; Franco Locatelli; Vilma Gabutti; Ugo Ramenghi; Michele D’Avanzo; Guido Paolucci; Pasquale Rosito; Andrea Pession; Melvin H Freedman

Book ID
114217320
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
361 KB
Volume
27
Category
Article
ISSN
0301-472X

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Deficient proliferation of myeloid, erythroid, and multipotent progenitor cells in long-term marrow cultures from patients with aplastic anemia treated with immunosuppressive therapy
✍ Gómez-Morales, Enrique; Martínez-Jaramillo, Guadalupe; Sánchez-Valle, Elizabeth; 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 87 KB 👁 2 views

By using Dexter-type long-term marrow cultures (D-LTMC), it has been shown previously that hematopoietic progenitor cells (HPC) from patients with aplastic anemia (AA) have a deficient proliferation in vitro. The studies reported to date, however, have focused exclusively on granulomonocytic progeni