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Long-term biocompatibility of implanted polymer-based intrafascicular electrodes

✍ Scribed by Lawrence, Stephen M. ;Larsen, Jytte O. ;Horch, Kenneth W. ;Riso, Ron ;Sinkjaer, Thomas

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
525 KB
Volume
63
Category
Article
ISSN
0021-9304

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✦ Synopsis

Polymer-based longitudinal intrafascicular electrodes (polyLIFEs) were chronically implanted into the sciatic nerve of white New Zealand rabbits (n=8) for a period of 6 months (hereafter referred to as the long-term group). The impact of the implantation procedure, as observed 6 months post surgery, was evaluated in a sham-treated control group (n=9). The contralateral sciatic nerve served as the control for each animal. Nerve-fiber counts, fiber diameters, and myelin thickness were estimated at the level of the implant site, 1.5 cm proximally, and 1.5 cm distally for both nerves in sham-treated and long-term groups. Implantation of polyLIFEs had no significant effect on fiber counts, nerve-fiber diameter, or myelin thickness. A slight increase in connective tissue in the vicinity of the implant site was evident in the long-term group, including a thin but dense capsule immediately surrounding the implanted electrode.

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