Long-term benefits of aggressive treatment for primary colorectal cancer

✍ Scribed by Klein, Peter; Allison, David; Khuder, Sadik; Walsh, Arlene; Khan, Zeenat; Smith, Daniel; Webb, Thomas

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 844 KB
• Volume: 62
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/(sici)1096-9098(199608)62:4<258::aid-jso7>3.0.co;2-5

✦ Synopsis

The long-term follow up of 128 colorectal cancer patients is reported. Seventy-nine percent (101/128) of the patients had curative resections: 70 patients had radical lymphadenectomies with wide removal of tumoradjacent nodes, and 31 patients had standard resections. The 5-year overall survival rates for Dukes' stage B and C patients and for all rectosigmoid cancer patients significantly favored radical resection (60% vs. 3896, 57% vs. 29%, respectively, P < 0.05). Tumor-free survival rates were also higher after radical lymphadenectomy but did not reach statistical significance. Eleven percent (14/128) of the patients required multiorgan resections, and/or preoperative radiation to render fixed cancers resectable, and these patients had a 10-year tumor-free survival rate of 4.5%. compared to zero % 5-year survival for the 27 patients who underwent palliative procedures ( P < 0.01). These results confirm that many colorectal cancer patients will be cured with aggressive treatment and they support the need for a controlled trial for evaluation of lymphadenectomy for this disease.