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Long-Term Behavioral Changes After Cessation of Chronic Antidepressant Treatment in Olfactory Bulbectomized Rats

โœ Scribed by Megan E. Breuer; Lucianne Groenink; Ronald S. Oosting; Herman G.M. Westenberg; Berend Olivier


Book ID
119197394
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
249 KB
Volume
61
Category
Article
ISSN
0006-3223

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The olfactory bulbectomized (OB) rat has been developed as an animal model of depression. In the novel `open ยฎeld' environment, OB rats showed a hyperactivity which was attenuated by chronic treatment with desipramine (7 . 5 mg/ kg) for 20 days. Neutrophil phagocytosis was suppressed by the lesion,