Long-standing colonic inflammation is associated with a low prevalence of diverticuli in inflammatory bowel disease patients
✍ Scribed by Adi Lahat; Benjamin Avidan; Simon Bar-Meir; Yehuda Chowers
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 89 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1078-0998
No coin nor oath required. For personal study only.
✦ Synopsis
Background:
Diverticulosis is associated with high intracolonic pressure and a weakened bowel wall. chronic colitis is characterized by liquid stools suggestive of low intracolonic pressure and a thickened bowel wall. therefore, the aim of this study was to assess the prevalence of diverticulosis in colitis patients.
Methods:
Colonoscopy results of patients with inflammatory bowel disease (ibd)-associated colitis older than 50 years were retrospectively evaluated and compared with those of patients who underwent screening colonoscopy. only patients with biopsy-proven disease, disease duration of more than 5 years, and disease beyond the distal 20 cm were included.
Results:
In all, 1037 patients were diagnosed by colonoscopy as suffering from ibd-associated colitis between 1987-2005. after exclusion of patients who did not meet the inclusion criteria the study population consisted of 314 ibd patients and 1023 age-matched control patients. a significantly higher percent of diverticuli was detected in the control group compared with the ibd group (15% versus 3.5%, p < 0.001). no significant difference in the prevalence of diverticuli was detected between the three subtypes of ibd patients (2% in ulcerative colitis versus 4.7% in crohn's colitis versus 7.6% in indeterminant colitis). neither disease duration nor the specific colonic segment involved had a significant influence on the prevalence of diverticulosis.
Conclusions:
Long-standing colonic inflammation in ibd patients is associated with a lower prevalence of diverticuli.