Long Noncoding RNAs: Structures and Functions

✍ Scribed by Riki Kurokawa (eds.)

• Publisher: Springer Japan
• Year: 2015
• Tongue: English
• Leaves: 252
• Edition: 1
• Category: Library

✦ Synopsis

This book presents a common principle of actions of long noncoding RNAs (lncRNAs) from points of view at the atomic, molecular and cellular levels. At the atomic level, chemical studies of ribonucleic acids explain the chemical behavior of lncRNAs. Structural biological analysis of lncRNAs and its binding proteins also reveal the precise mechanisms of their actions. Molecular biological approaches lead to insights into molecular mechanisms of these lncRNA actions. At the cellular or individual level of analysis, we grasp the biology and medicine of lncRNAs. These three layers of approaches are thoroughly new and produce novel insights into functions of lncRNAs in living cells. The book consists of five parts: 1) Bioinformatics and other methodologies for lncRNAs, 2) Atomic and molecular structures of lncRNAs, 3) Molecular functions of lncRNAs, 4) Biological actions of lncRNAs, and 5) Potential outcomes for clinical medicine. These sections connect well and work synergistically. The book is for researchers whose specialty is RNA biology and chemistry and also for advanced students at the graduate and undergraduate levels. Readers can grasp the leading edge of lncRNA studies in a comprehensive manner and are inspired to pursue their own particular interests.

✦ Table of Contents

Front Matter....Pages i-viii
Front Matter....Pages 1-1
Complexity of Mammalian Transcriptome Analyzed by RNA Deep Sequencing....Pages 3-22
Synthetic Strategies to Identify and Regulate Noncoding RNAs....Pages 23-43
Front Matter....Pages 45-45
Structure and Interaction with Protein of Noncoding RNA: A Case for an RNA Aptamer Against Prion Protein....Pages 47-56
Characterization of G-Quadruplex DNA- and RNA-Binding Protein....Pages 57-65
Front Matter....Pages 67-67
Initiation of Transcription Generates Divergence of Long Noncoding RNAs....Pages 69-91
Beneath the Veil of Biological Complexity There Lies Long Noncoding RNA: Diverse Utilization of lncRNA in Yeast Genomes....Pages 93-110
Long Noncoding RNAs as Structural and Functional Components of Nuclear Bodies....Pages 111-129
Front Matter....Pages 131-131
Long Noncoding RNA in Epigenetic Gene Regulation....Pages 133-149
Mechanisms of Long Noncoding Xist RNA-Mediated Chromosome-Wide Gene Silencing in X-Chromosome Inactivation....Pages 151-171
Front Matter....Pages 173-173
Regulation of pRB and p53 Pathways by the Long Noncoding RNAs ANRIL, lincRNA-p21, lincRNA-RoR, and PANDA ....Pages 175-189
The Role of Androgen-Regulated Long Noncoding RNAs in Prostate Cancer....Pages 191-210
Macrophage Activation as a Model System for Understanding Enhancer Transcription and eRNA Function....Pages 211-229
Long Noncoding RNA Functions as a Regulator for Steroid Hormone Receptor-Related Breast and Prostate Cancers....Pages 231-249
Back Matter....Pages 251-257

✦ Subjects

Cell Biology; Gene Function; Nucleic Acid Chemistry