Long non-coding RNAs in nuclear bodies
โ Scribed by Joanna Y. Ip; Shinichi Nakagawa
- Book ID
- 108944310
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 293 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0012-1592
No coin nor oath required. For personal study only.
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Common themes are emerging in the molecular mechanisms of long non-coding RNA-mediated gene repression. Long non-coding RNAs (lncRNAs) participate in targeted gene silencing through chromatin remodelling, nuclear reorganisation, formation of a silencing domain and precise control over the entry of g
The most well-studied sequences in the human genome are those of protein-coding genes. However, the coding exons of these genes account for only 1.5% of the genome, a proportion that increases to 2% if untranslated regions (UTRs) are considered 1 . In recent years, it has become increasingly apparen