Long- and short-term effects of transmyocardial laser revascularization in acute myocardial ischemia

✍ Scribed by Kadipasaoglu, Kamuran A.; Pehlivanoglu, Seckin; Conger, Jeff L.; Sasaki, Eisaku; de Villalobos, Diego H.; Cloy, Michael; Piluiko, Vitaly; Clubb, Fred J.; Cooley, Denton A.; Frazier, O. Howard

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 481 KB
• Volume: 20
• Category: Article
• ISSN: 0196-8092
• DOI: 10.1002/(sici)1096-9101(1997)20:1<6::aid-lsm2>3.0.co;2-u

✦ Synopsis

Background and objective:

This study examined the effect of transmyocardial laser revascularization (tmlr) on infarct size and global and regional left ventricular (lv) function.

Study design/materials and methods:

Acute ischemia was induced in 24 dogs by ligating the left anterior descending artery. tmlr was done through a left thoracotomy in 12 dogs. the 12 control dogs had ligation only. global and regional lv function were measured before ligation, then at 6 hours or 3 months after ligation. we calculated the volumetric ratio of damaged myocardium to myocardium at risk (vd/vr).

Results:

At 6 hours, global compensation despite regional dyskinesia was universal; vd/vr was the same in control and tmlr dogs. at 3 months, global function during stress was significantly higher in tmlr dogs than in control dogs (p < .05); regional contractions were synergic only in tmlr dogs; mean vd/vr was significantly lower in tmlr dogs.

Conclusion:

Tmlr limits infarct expansion and improves long-term global and regional function after acute ischemia.