In comparing two treatments under a typical sequential clinical trial setting, a 50-50 randomization design generates reliable data for making efficient inferences about the treatment difference for the benefit of patients in the general population. However, if the treatment difference is large and
LOGRANK, PLAY THE WINNER, POWER AND ETHICS
β Scribed by AL HALLSTROM; MARIA MORI BROOKS; MONIKA PECKOVA
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 486 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0277-6715
No coin nor oath required. For personal study only.
β¦ Synopsis
We show by simulation and numerical integration techniques that power is largely unaffected by play the winner strategies in a typical chronic disease mortality trial utilizing the logrank test. This raises the issue of the ethics of equal allocation in such a setting.
π SIMILAR VOLUMES
We consider a clinical trial model comparing an experimental treatment with a control treatment when the responses are binary. For fixed significance level and power, we compare the expected number of treatment failures for two designsthe randomized play-the-winner rule and the triangular test. The