Locomotor activity following intra-accumbens microinjections of dopamine D1 agonist SK&F 38393 in rats

✍ Scribed by Dr. Merle E. Meyer; Carol van Hartesveldt; Thomas J. Potter

• Book ID: 104600483
• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 507 KB
• Volume: 13
• Category: Article
• ISSN: 0887-4476
• DOI: 10.1002/syn.890130403

✦ Synopsis

The present study examined the effects of the dopamine D, receptor subtypes agonist SK&F 38393 on locomotor activities after bilateral microinjection (0.00, 0.01, 0.1, 1.0,lO.O Fg) into the nucleus accumbens (Acb). The dose of 0.1 Fg elicited the highest response rate across measures of locomotion, rearing and stereotypy behavior. On the other hand, the largest dose of 10.0 pg was associated with significant increase in center time behaviors. The data were supportive of the hypothesis that dose-related locomotor activities elicited by microinjections of SK&F 38393 into the Acb are independently mediated by D, receptors.