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Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human α-synuclein

✍ Scribed by Leonid Yavich; Mari Oksman; Heikki Tanila; Petri Kerokoski; Mikko Hiltunen; Thomas van Groen; Jukka Puoliväli; Pekka T. Männistö; Arturo García-Horsman; Ewen MacDonald; Konrad Beyreuther; Tobias Hartmann; Pekka Jäkälä

Book ID: 113811846
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 370 KB
Volume: 20
Category: Article
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2005.03.010

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## Abstract Overexpression or mutation of α‐synuclein (α‐Syn), a protein associated with presynaptic vesicles, causes familial forms of Parkinson's disease in humans and is also associated with sporadic forms of the disease. We used in vivo microdialysis, tissue content analysis, behavioral assessm