Location ofLy-7on mouse chromosome 12

✍ Scribed by P. M. Hogarth; I. F. C. McKenzie; L. Lanier; D. W. Bailey; B. A. Taylor

• Publisher: Springer-Verlag
• Year: 1984
• Tongue: English
• Weight: 250 KB
• Volume: 19
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00403445

✦ Synopsis

The Ly-7 locus was originally described (McKenzie and Potter 1979) by an alloantibody made with the CXB recombinant inbred strains as (B6.C-H-2 d x CXBG)F1 anti-CXBK. The strain distribution was unique and all strains tested, except C57BL/6, C57BL/10, and C58, were reactive with the antibody, i. e., were Ly-7.2 +. More recently a monoclonal antibody to the Ly-7.2 specificity was produced (Lanier and Warner 1982) and a third allele and specificity (Ly-7.3) described (Lanier and Warner 1983). The Ly-7.1 specificity appears to have a restricted tissue distribution, being found only on lymphocytes and in higher concentrations on B cells than on T cells (Potter et al. 1980). However, within T cells, Ly-7.1 has been found to be a useful marker in identifying T-cell subsets (M. C. Michaelides and I. F. C. McKenzie, personal communication). In this study we describe the linkage of Ly-7 to Pre-1 and Igh-1 on chromosome 12 (results based on the use of recombinant inbred (RI) strains of mice). B6.C-H W bilineal congenic strains were also typed but were not informative.