Location, location, location: the CNS sites of leptin action dictate its regulation of homeostatic and hedonic pathways

The angiopoietin-2 gene of endothelial c

The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1

✍ Marie-Pierre Simon; Roselyne Tournaire; Jacques Pouyssegur 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 292 KB 👁 1 views

## Abstract Angiopoietins are ligands of the endothelial cell tyrosine kinase receptor Tie2. Angiopoietin‐1 (Ang‐1) is widely expressed in human normal adult tissues and promotes blood vessel maturation and stabilization by inducing Tie2 receptor phosphorylation. In contrast, the antagonistic ligan