Locally applied nerve growth factor enhances bone consolidation in a rabbit model of mandibular distraction osteogenesis

Axial shortening during distraction oste

Axial shortening during distraction osteogenesis leads to enhanced bone formation in a rabbit model through the HIF-1α/vascular endothelial growth factor system

✍ Shigeshi Mori; Masao Akagi; Aiichiro Kikuyama; Yoshiko Yasuda; Chiaki Hamanishi 📂 Article 📅 2006 🏛 Elsevier Science 🌐 English ⚖ 567 KB

Axial micromotion of bone fragments enhances callus formation during fracture repair or limb lengthening. To examine this, we used an axial-shortening model of the tibial callus in rabbits and performed histological analyses. After 10-mm lengthening of the left tibia with an external fixator, we sho