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Localized 13C NMR spectroscopy of myo-inositol in the human brain in vivo

✍ Scribed by Rolf Gruetter; Douglas L. Rothman; Edward J. Novotny; Robert G. Hulman

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
477 KB
Volume
25
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Natural abundance ^13^C NMR spectra obtained from 144‐cm^3^volumes in the human brain contained well‐resolved resonances of myo‐inositol after 60 min of data accumulation. A mean concentration of 7.2 Β± 0.5 pmol/g (Β±SE, n = 7) was calculated from the comparison with phantoms. ^13^C NMR spectroscopy thus provides a complementaryrole in the quantitation of metabolites also observed in the crowded ^1^H spectrum.

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