Localization ofd-serine and serine racemase in neurons and neuroglias in mouse brain
✍ Scribed by Xiaohui Ding; Ning Ma; Masato Nagahama; Kumiko Yamada; Reiji Semba
- Publisher
- Springer Milan
- Year
- 2010
- Tongue
- English
- Weight
- 410 KB
- Volume
- 32
- Category
- Article
- ISSN
- 1590-1874
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## Abstract Serine racemase (SR) is responsible for the biosynthesis of D‐serine (D‐Ser), an endogenous co‐agonist for __N__‐methyl‐D‐aspartate (NMDA) receptors, from L‐serine (L‐Ser) in the central nervous system. In the present study, we investigated the role of SR in the regulation of chondrogen
## Abstract D‐serine is an endogenous N‐methyl‐D‐aspartate (NMDA) receptor coagonist. It is synthesized from L‐serine by serine racemase (SRR), but many aspects of its metabolism remain unclear, especially in the forebrain, which lacks active D‐amino acid oxidase (DAO), the major D‐serine degradati