Localization of X chromosome short arm markers relative to synovial sarcoma- and renal adenocarcinoma-associated translocation breakpoints
✍ Scribed by R. J. Sinke; B. Leeuw; H. A. P. Janssen; D. Olde Weghuis; R. F. Suijkerbuijk; A. M. Meloni; S. Gilgenkrantz; W. Berger; H. H. Ropers; A. A. Sandberg; A. Geurts Kessel
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 553 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0340-6717
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✦ Synopsis
A series of thirteen different DNA markers was mapped relative to papillary renal cell carcinoma- and synovial sarcoma-associated translocation breakpoints in Xp11.2 using a panel of tumor-derived somatic cell hybrids in conjunction with Southern blot analysis. Our results indicate that the two translocation breakpoints differ from each other and that the chromosomal break in t(X;1)-positive papillary renal cell carcinoma is located between the markers PFC-TIMP-OATL1-SYP-TFE3 and DXS226-DXS146-DXS255-OATL2-DXS14. In addition, our current breakpoint analysis has resulted in a revision of the regional localization of the proximal Xp marker DXS226.