Localization of the α2-macroglobulin gene andLpmgene family on mink chromosome 9

✍ Scribed by V. I. Yermolaev; G. I. Karasik; T. M. Khlebodarova; N. M. Matveeva; M. R. Mullakandov; A. M. Nayakschin; T. V. Shumny; N. B. Rubtsov; O. L. Serov; O. K. Baranov

• Publisher: Springer
• Year: 1989
• Tongue: English
• Weight: 516 KB
• Volume: 78
• Category: Article
• ISSN: 0040-5752
• DOI: 10.1007/bf00299760

✦ Synopsis

Using cloned cDNA for human α2-macroglobulin (A2M) as a probe, mink-Chinese hamster hybrid cells were analysed. The results allowed us to assign a gene for A2M to mink chromosome 9. Breeding tests demonstrated that the Lpm-locus coding for other related α-macroglobulin protein and the gene for peptidase B (PEPB) are linked 11±3 cm apart. The PEPB gene is located on mink chromosome 9, and hence, the Lpw-locus is on the same mink chromosome. The relationship of the genetic systems controlling the isotypically different α-macroglobulins in mink serum are discussed.