Localization of the subthalamic nucleus in Parkinson disease using multiunit activity
โ Scribed by Peter Novak; Andrzej W. Przybyszewski; Andrei Barborica; Paula Ravin; Lee Margolin; Julie G. Pilitsis
- Book ID
- 119304215
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 769 KB
- Volume
- 310
- Category
- Article
- ISSN
- 0022-510X
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The role of the subthalamic nucleus (STN) in the origin of parkinsonian tremor is discussed. Previous studies in monkeys made parkinsonian by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) administration suggested a direct participation of the STN in the pathophysiology of tremor. We recorded t
Microelectrode recordings of single unit neuronal activity were used during stereotactic surgery to define the subthalamic nucleus for chronic deep brain stimulation in the treatment of Parkinson's disease. By using five parallel trajectories, often two to three microelectrodes allow us to recognize