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Localization of receptors for endocytosis of lysosomal enzymes on different brain cells

✍ Scribed by P. Schluff; B. Flott-Rahmel; V. Gieselmann; P. Zimmer; A. Das; K. Ullrich

Book ID
110222577
Publisher
Springer
Year
1998
Tongue
English
Weight
76 KB
Volume
21
Category
Article
ISSN
0141-8955

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Liver sinusoidal endothelial cells (LSECs) are largely responsible for the removal of circulating lysosomal enzymes (LE) via mannose receptor (MR)-mediated endocytosis. We hypothesized that LSECs rely on this uptake to maintain their extraordinarily high degradation capacity for other endocytosed ma