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Localization of Rabphilin-3A, a Putative Target Protein for Rab3A, at the Sites of Ca2+-Dependent Exocytosis in PC12 Cells

✍ Scribed by K. Wada; A. Mizoguchi; K. Kaibuchi; H. Shirataki; C. Ide; Y. Takai

Book ID: 115574058
Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 592 KB
Volume: 198
Category: Article
ISSN: 0006-291X
DOI: 10.1006/bbrc.1994.1023

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## Abstract **Background:** Rab3A, a member of the Rab3 small G protein family, regulates Ca^2+^‐dependent exocytosis of neurotransmitter. The cyclical activation and inactivation of Rab3A are essential for the Rab3A action in exocytosis. GDP‐Rab3A is activated to GTP‐Rab3A by Rab3 GDP/GTP exchange