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Localization of leukotriene D4-metabolizing metalloenzyme on the cell surface of human neutrophils

โœ Scribed by Isao Nagaoka; Tatsuhisa Yamashita

Book ID
119120395
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
558 KB
Volume
888
Category
Article
ISSN
0167-4889

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Effect of structural modification at carbon atom 1 of leukotriene B4 on the chemotactic and metabolic response of human neutrophils
โœ Robert M. Clancy; Clemens A. Dahinden; Tony E. Hugli ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 801 KB

Human neutrophils biosynthesize the chemoattractant leukotriene B4 (LTB4) and metabolize LTB4 to omega oxidative products 20-hydroxy-LTB4 (20-OH-LTB4) and 20-carboxy-LTB4 (20-COOH-LTB4). In this study, we prepared the C-1 methyl ester and N-methyl amide of LTB4 and then examined neutrophil chemotaxi