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Localization of growth arrest-specific genes on mouse Chromosomes 1, 7, 8, 11, 13, and 16

✍ Scribed by Mario P. Colombo; Alessia Martinotti; Thad A. Howard; Claudio Schneider; Peter D'Eustachio; Michael F. Seldin


Publisher
Springer-Verlag
Year
1992
Tongue
English
Weight
749 KB
Volume
2
Category
Article
ISSN
0938-8990

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✦ Synopsis


Growth arrest in NIH3T3 cells is associated with increased expression of a variety of mRNAs, several of which have been isolated as cDNA clones. Six of these growth arrest-specific (Gas) genes were mapped by following the inheritance of DNA restriction fragment length variants (RFLVs) associated with them in panels of recombinant inbred (RI) strains of mice and in the progeny of backcrosses both between laboratory mouse strains and between a laboratory strain and Mus spretus. The six genes are unlinked. Gas-1 maps to Chromosome (Chr) 13, Gas-2 to Chr 7, Gas-3 to Chr 11, Gas-4 to Chr 16, Gas-6 to Chr 8, and Gas-10 to Chr 1.


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