Localization of growth arrest-specific genes on mouse Chromosomes 1, 7, 8, 11, 13, and 16
β Scribed by Mario P. Colombo; Alessia Martinotti; Thad A. Howard; Claudio Schneider; Peter D'Eustachio; Michael F. Seldin
- Publisher
- Springer-Verlag
- Year
- 1992
- Tongue
- English
- Weight
- 749 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0938-8990
No coin nor oath required. For personal study only.
β¦ Synopsis
Growth arrest in NIH3T3 cells is associated with increased expression of a variety of mRNAs, several of which have been isolated as cDNA clones. Six of these growth arrest-specific (Gas) genes were mapped by following the inheritance of DNA restriction fragment length variants (RFLVs) associated with them in panels of recombinant inbred (RI) strains of mice and in the progeny of backcrosses both between laboratory mouse strains and between a laboratory strain and Mus spretus. The six genes are unlinked. Gas-1 maps to Chromosome (Chr) 13, Gas-2 to Chr 7, Gas-3 to Chr 11, Gas-4 to Chr 16, Gas-6 to Chr 8, and Gas-10 to Chr 1.
π SIMILAR VOLUMES
## Wild -type P16ICDKNZ MTSI) cDNA, directed by the cytomegalovirus (CMV) immediate early promoter, was transfected into RT4 and RTI I 2 bladder-carcinoma cell lines bearing a mutated endogenous P16ICDKNZ gene and lacking endogenous P 16lCDKN2 respectively. In both cases, only transfected clones w