✦ LIBER ✦

Localization of GM1 and GD1b antigens in the human peripheral nervous system

✍ Scribed by Susumu Kusunoki; Atsuro Chiba; Tadashi Tai; Tadashi Tai; Ichiro Kanazawa

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 503 KB
Volume: 16
Category: Article
ISSN: 0148-639X
DOI: 10.1002/mus.880160710

No coin nor oath required. For personal study only.

✦ Synopsis

Serum antibodies against ganglioside GM1 and/or GD1 b are frequently detected in autoimmune neuropathies such as multifocal motor neuropathy, IgM paraproteinemic neuropathy and Guillain-Barre syndrome. Some of them bind to GMI or GD1 b monospecifically but others cross-react with both of the antigens. In order to investigate the respective localizations of GMI and GDlb antigens in the human peripheral nervous system, an immunohistochemical study was performed using two mouse monoclonal antibodies, each monospecific to GMI and GDl b. GGR12, monospecific to GD1 b, bound to neurons in dorsal root ganglia and sympathetic ganglia, and some parts of the peripheral myelin, mainly the paranodal areas. However GMB16, monospecific to GM1, did not bind to either neurons or myelin. GD1 b antigen present on neurons and paranodal myelin in the peripheral nervous system can be a target antigen of serum antibodies in autoimmune neuropathies. Further effort should be made to reveal the localization of GMI antigen in the human peripheral nervous system.

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