✦ LIBER ✦

Localization of endostatin in rat and human gliomas

✍ Scribed by Herwig M. Strik; Hermann J. Schluesener; Karin Seid; Richard Meyermann; Martin H. Deininger

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 563 KB
Volume: 91
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(20010301)91:5<1013::aid-cncr1092>3.0.co;2-q

No coin nor oath required. For personal study only.

✦ Synopsis

BACKGROUND. Endostatin is a potent inhibitor of endothelial cell proliferation, angiogenesis, and tumor growth. Its occurrence and localization has not yet been examined in human brain tumors. The authors report the production of a monoclonal antibody and detection of endostatin in rat and human gliomas by immunohistochemistry. METHODS. The authors analyzed localization and tissue distribution of endostatin in 41 paraffin embedded glioma samples (18 glioblastoma multiforme, 7 WHO Grade III astrocytomas, 13 fibrillary, and 3 protoplasmic WHO Grade II astrocytomas) of human origin and 21 rat C6 gliomas by immunohistochemistry. Double labeling experiments confirmed the origin of endostatin-labeled cells.

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