Localization of dystrophin in cultures of human muscle
β Scribed by Dr. Marion S. Ecob-Prince; Mark A. Hill; Aileen E. Brown
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 390 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0148-639X
No coin nor oath required. For personal study only.
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## Abstract Dystrophin and dystrophinβassociated proteins (DAPs) form a complex around the sarcolemma, which gives stability to the sarcolemma and leads signal transduction. Recently, the nuclear presence of dystrophin Dp71 and DAPs has been revealed in different nonβmuscle cell types, opening the
Dystrophin, the protein product defective in Duchenne muscular dystrophy (DMD), is present in all types of muscle and in the brain. The function of the protein is unknown and its role in the brain is unclear, although 30% of DMD patients show nonprogressive mental retardation. We have therefore stud