✦ LIBER ✦

Localization of anti-osteogenic sarcoma monoclonal antibody 791T/36 in a primary human osteogenic sarcoma and its subsequent xenograft in immunodeprived mice

✍ Scribed by Malcolm V. Pimm; Alan C. Perkins; Nicholas C. Armitage; Robert W. Baldwin

Book ID: 104660543
Publisher: Springer-Verlag
Year: 1985
Tongue: English
Weight: 951 KB
Volume: 19
Category: Article
ISSN: 0340-7004
DOI: 10.1007/bf00199306

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✦ Synopsis

A primary human osteogenic sarcoma was visualized in situ by external gamma-camera imaging following administration of 131I-labelled anti-osteogenic sarcoma monoclonal antibody 791T/36. A xenograft of the tumour established in immunodeprived mice also showed localization of 1311-791T/36 determined by both gamma-camera imaging and organ distribution studies. Radiolabelled normal immunoglobulin showed no tumour localization. Expression of the 791T/36-defined antigen on xenografted tissue was further confirmed by reaction of its in vitro-cultured cells with fluorescein-labelled 791T/36 antibody.

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