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Localization of a tumour-suppressor gene associated with human oral cancer on 7q31.1

✍ Scribed by Xiao-Li Wang; Katsuhiro Uzawa; Akihisa Miyakawa; Masashi Shiiba; Toshihide Watanabe; Takeyuki Sato; Tsuneo Miya; Hidetaka Yokoe; Hideki Tanzawa

Publisher: John Wiley and Sons
Year: 1998
Tongue: French
Weight: 114 KB
Volume: 75
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19980302)75:5<671::aid-ijc2>3.0.co;2-w

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✦ Synopsis

To search for the existence of a tumour-suppressor gene (TSG) associated with oral squamous cell carcinoma (SCC), PCR analysis of microsatellite polymorphisms corresponding to 14 loci which map to chromosome 7q21.3-qter was performed to screen 35 patients with oral SCC for loss of heterozygosity (LOH). LOH was observed in at least one of the loci in 19 of 34 (55.9%) informative cases. Among the loci tested, frequent LOH was restricted at D7S522 on chromosome 7q31.1, which was measured within 1 cM. Furthermore, we detected microsatellite instability (MI) in 11 of 35 (31.4%) cases tested. Our observations indicate that alterations of chromosome 7q are associated with oral SCC tumorigenesis and that 7q31.1 might harbour at least one putative TSG. Int.

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