An Austrian family with nonsyndromic Xlinked mental retardation (MRX) is reported in which the obligatory carrier females are normal, and 5 affected males have mild to moderate mental retardation. Linkage analysis indicated an X pericentromeric localization, with flanking markers DXS989 and DXS1111
Localization of a Gene Responsible for Nonspecific Mental Retardation (MRX9) to the Pericentromeric Region of the X Chromosome
β Scribed by Patrick Willems; Lieve Vits; Inge Buntinx; Peter Raeymaekers; Christine Van Broeckhoven; Berten Ceulemans
- Book ID
- 115611832
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 263 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0888-7543
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## Linkage analysis was performed on a fourgeneration family with nonspecific mental retardation (MRX59 ). The five affected males, ranging in age from 2 years to 52 years, have a normal facial appearance and mild to severe mental impairment. Four obligate carriers are physically normal and not ret
Nonspecific X-linked mental retardation is a heterogeneous condition consisting of nonsyndromal mental retardation in males. It is caused by mutation in one of several genes on the X chromosome (MRX genes). Here we report on the localization of a presumptive MRX gene to chromosomal region Xq24-q26 i