Localization of 1,25-dihydroxyvitamin D3 receptor (VDR) expression in human prostate
✍ Scribed by Merja Kivineva; Merja Bläuer; Heimo Syvälä; Teuvo Tammela; Pentti Tuohimaa
- Book ID
- 117669031
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 300 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0960-0760
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The vitamin D receptor (VDR) is a nuclear receptor that mediates the effect of the active metabolite of vitamin D3, the 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3). To investigate the potential role of this hormone in the peripheral nervous system, we have studied the VDR expression in Schwann cells. Th
## Abstract Upregulation of p27^Kip1^ protein in 1,25‐dihydroxyvitamin D~3~‐treated cancer cells is mediated via enhancement of gene transcription and reduction of protein degradation. 1,25‐dihydroxyvitamin D~3~ inhibits the expression of p45^Skp2^, the F‐box protein which is implicated in p27^Kip1