Localization and functional roles of corticotropin-releasing factor receptor type 2 in the cerebellum
β Scribed by Natalia V. Gounko; Albert Gramsbergen; Johannes J. L. van der Want
- Book ID
- 107648188
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 254 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1473-4222
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## Abstract Corticotropin releasing factor (CRF), localized in afferent inputs to the cerebellum, binds to two receptors defined as the Type 1 (CRFβR1) and the Type 2 (CRFβR2Ξ±). CRFβR1 has been localized to the cerebellum, as has a truncated isoform of CRFβR2Ξ±. Evidence for the presence of the full
## Abstract Corticotropin releasing factor (CRF) and its cognate receptors, defined as Type 1 and Type 2 have been localized within the cerebellum. The Type 2 CRF receptor (CRFβR2) is known to have both a full length (CRFβR2Ξ±) and a truncated (CRFβR2Ξ±βtr) isoform. A recent study documented CRFβR2Ξ±
## Abstract Corticotropinβreleasing factor agonists exert inhibitory effects in stomach functions possibly through peripheral routes. We have previously reported the expression of Urocortin (Ucn) I, an endogenous ligand of both CRF receptor types CRF~1~ and CRF~2~, in the human stomach. We examined