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Localization and biodistribution of conjugate ATG-Dex-DNR in nude mice as models for human leukemia

โœ Scribed by Dong-hua, Zhang ;Jin-zhi, Tang ;Zhi-xiong, Li ;Wu-ien, Cui ;Hua, Wu ;Hui-fen, Zhu ;Guan-xin, Shen

Book ID
112927620
Publisher
Springer-Verlag
Year
1995
Tongue
English
Weight
536 KB
Volume
15
Category
Article
ISSN
0257-716X

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The blood kinetics and tumour localization of a conjugate of methotrexate (MTX) and MAb 791T136 were examined i n nude mice with human tumour xenografts. The antibod moiety of the conjugate was detected by labelling with l2J and the drug moiety was assayed using a radioimmunoassay for methotrexate.